AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.

@article{Waligora2010AmrZBR,
  title={AmrZ beta-sheet residues are essential for DNA binding and transcriptional control of Pseudomonas aeruginosa virulence genes.},
  author={Elizabeth A. Waligora and Deborah M Ramsey and Edward E. Pryor and Haiping Lu and Thomas Hollis and Gina Parise Sloan and Rajendar Deora and Daniel J Wozniak},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 20},
  pages={
          5390-401
        }
}
AmrZ is a putative ribbon-helix-helix (RHH) transcriptional regulator. RHH proteins utilize residues within the β-sheet for DNA binding, while the α-helices promote oligomerization. AmrZ is of interest due to its dual roles as a transcriptional activator and as a repressor, regulating genes encoding virulence factors associated with both chronic and acute Pseudomonas aeruginosa infection. In this study, cross-linking revealed that AmrZ forms oligomers in solution but that the amino terminus… CONTINUE READING
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