Amplitude-dependent stress fiber reorientation in early response to cyclic strain.

Almost all types of cells in vivo are constantly subjected to mechanical deformation derived from muscular movement, respiration, or blood pulsation. In order to elucidate how cells and their cytoskeletal components respond to these stimuli, we developed a new device which can apply a wide range of uniaxial cyclic strain to cultured cells. When the cells… CONTINUE READING