Amplitude and kinetics of action potential-evoked Ca2+ current and its efficacy in triggering transmitter release at the developing calyx of Held synapse.

@article{Yang2006AmplitudeAK,
  title={Amplitude and kinetics of action potential-evoked Ca2+ current and its efficacy in triggering transmitter release at the developing calyx of Held synapse.},
  author={Yi-mei Yang and L Y Wang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 21},
  pages={5698-708}
}
Action potentials (APs) play a crucial role in evoking Ca2+ currents (ICa) through voltage-gated calcium channels (VGCCs) and transmitter release. During development and neuromodulation, both depolarization and repolarization phases of APs change, but how such changes affect the characteristics of ICa and its efficacy at central synapses is not clear. By paired voltage-clamp recordings of ICa and excitatory postsynaptic currents (IEPSC) with pseudo-APs and real APs, we examined these issues in… CONTINUE READING

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Regulation of transmitter release at the squid giant synapse by presynaptic delayed rectifier potassium current

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