• Corpus ID: 21841089

Amplitude/intensity functions of auditory event-related potentials predict responsiveness to bupropion in major depressive disorder.

@article{Paige1995AmplitudeintensityFO,
  title={Amplitude/intensity functions of auditory event-related potentials predict responsiveness to bupropion in major depressive disorder.},
  author={Stephen R. Paige and Shelton E. Hendricks and Denis F. Fitzpatrick and Scott E. Balogh and William J Burke},
  journal={Psychopharmacology bulletin},
  year={1995},
  volume={31 2},
  pages={
          243-8
        }
}

• S. Paige, S. Hendricks, +2 authors W. Burke
• Published 1995
• Psychology, Biology
• Psychopharmacology bulletin

Patients diagnosed with major depressive disorder (MDD) and enrolled in an open-label safety surveillance study of a sustained release formulation of bupropion hydrochloride (100 to 300 mg/day) were evaluated with the Hamilton Rating Scale for Depression (HAM-D) immediately before and 6 to 12 weeks after the initiation of drug treatment. Auditory event-related potentials (ERPs) recorded under a stimulus intensity modulation paradigm were also obtained at these times. Patients were classified as responders and nonresponders based on post-treatment HAM-D scores, with responders having HAM-D scores less than 10 and nonresponders having scores greater than 10. Consistent with our previous findings, responders exhibited significantly larger positive slope coefficients for P2 ERP component amplitudes as a function of auditory stimulus intensity obtained at baseline and were not affected by bupropion treatment. Thus, these results further support our previous finding that ERP amplitude/intensity functions measured under a stimulus intensity modulation paradigm provide information about the likelihood of a positive therapeutic response to antidepressant pharmacotherapy in patients with MDD and extends these results to bupropion, a pharmacologically atypical antidepressant agent.