Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis.

@article{Sibinska2017AmplifiedCT,
  title={Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis.},
  author={Zaneta Sibinska and Xia Tian and Martina Korfei and Baktybek Kojonazarov and Janina Susanne Kolb and Walter Klepetko and Djuro Kosanovic and Malgorzata Wygrecka and Hossein Ardeschir Ghofrani and Norbert Weissmann and Friedrich Grimminger and Werner Seeger and Andreas G{\"u}nther and Ralph Theo Schermuly},
  journal={The European respiratory journal},
  year={2017},
  volume={49 2}
}
Interstitial lung fibroblast activation coupled with extracellular matrix production is a pathological signature of idiopathic pulmonary fibrosis (IPF), and is governed by transforming growth factor (TGF)-β/Smad signalling. We sought to define the role of heat shock protein (HSP)90 in profibrotic responses in IPF and to determine the therapeutic effects of HSP90 inhibition in a murine model of pulmonary fibrosis.We investigated the effects of HSP90 inhibition in vitro by applying 17-AAG (17… CONTINUE READING
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