Amplified Micromagnetic Field Gradients Enable High-Resolution Profiling of Rare Cell Subpopulations.

@article{Poudineh2017AmplifiedMF,
  title={Amplified Micromagnetic Field Gradients Enable High-Resolution Profiling of Rare Cell Subpopulations.},
  author={Mahla Poudineh and Edward H Sargent and Shana O. Kelley},
  journal={ACS applied materials & interfaces},
  year={2017},
  volume={9 31},
  pages={
          25683-25690
        }
}
Analyzing small collections of cells is challenging because of the need for extremely high levels of sensitivity. We recently reported a new approach, termed magnetic ranking cytometry (MagRC), to profile nanoparticle-labeled cells. Using antibody-functionalized magnetic nanoparticles, we label cells so that each cell's magnetization is proportional to its surface expression of a selected biomarker. Using a microfluidic device that sorts the cells into 100 different zones based on magnetic… CONTINUE READING

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