Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.

@article{Winner2007AmplificationOT,
  title={Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization.},
  author={Millicent G Winner and Albert C. Koong and Beatriz E. Rendon and Wayne Zundel and Robert Mitchell},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={186-93}
}
Low oxygen tension-mediated transcription by hypoxia-inducible factors (HIF) has been reported to facilitate tumor progression, therapeutic resistance, and metastatic adaptation. One previously described target of hypoxia-mediated transcription is the cytokine/growth factor macrophage migration inhibitory factor (MIF). In studies designed to better understand hypoxia-stimulated MIF function, we have discovered that not only is MIF induced by hypoxia in pancreatic adenocarcinoma but MIF is also… CONTINUE READING

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Regulation of macrophage migration inhibitory factor (MIF) and Cancer

  • H Jung, T Kim, HZ Chae, KT Kim, H. Ha
  • Research Cancer Res
  • 2007

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