Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.

Abstract

OBJECTIVE To determine the signal transduction pathways in CD14+ synovial cells from patients with rheumatoid arthritis (RA) after CD40 ligation, and to examine their role in amplifying synovial inflammation in affected joints. METHODS Expression of messenger RNA was analyzed using quantitative reverse transcription-polymerase chain reaction. Cytokines… (More)

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@article{Harigai2004AmplificationOT, title={Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.}, author={Masayoshi Harigai and M. Oberman Hara and Manabu Kawamoto and Yasushi Kawaguchi and Tomoko Sugiura and Michi Tanaka and Miki Nakagawa and Hisae Ichida and Kae Takagi and Satomi Higami-Ohsako and Katsuhiko Shimada and Naoyuki Kamatani}, journal={Arthritis and rheumatism}, year={2004}, volume={50 7}, pages={2167-77} }