Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.

@article{Ghofrani2002AmplificationOT,
  title={Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension.},
  author={Hossein Ardeschir Ghofrani and Frank Rose and Ralph Theo Schermuly and Horst Olschewski and Ralph Wiedemann and Norbert Weissmann and Christian Schudt and Herrmann Tenor and Werner Seeger and Friedrich Grimminger},
  journal={Critical care medicine},
  year={2002},
  volume={30 11},
  pages={2489-92}
}
OBJECTIVE Aerosolized iloprost causes specific pulmonary vasodilation for about 60 mins in patients with severe primary and secondary pulmonary hypertension. Repeated daily inhalations are currently in use for chronic treatment. The aim of the current study was to evaluate if phosphodiesterase type 3 and 4 inhibition might amplify the prostanoid effect on pulmonary vasodilatation by stabilization of intracellular second messenger cyclic adenosine monophosphate. DESIGN Uncontrolled clinical… CONTINUE READING
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