Amplification of the prolactin receptor gene in mammary lobular neoplasia

  title={Amplification of the prolactin receptor gene in mammary lobular neoplasia},
  author={Danh Tran-Thanh and Nona C. R. Arneson and Melania Pintilie and Ardit Deliallisi and Keisha S. Warren and Anita L. Bane and Susan J Done},
  journal={Breast Cancer Research and Treatment},
The identification of lobular carcinoma in situ (LCIS) in a patient’s specimen confers an appreciable increased risk of development of future invasive mammary carcinoma. However, the study of LCIS presents a challenge as it is usually only recognized in fixed specimens. Recent advances in high throughput genomics have made possible comprehensive copy number analysis of lesions such as this. Using array comparative genomic hybridization (aCGH), we characterized eight cases of lobular carcinoma… CONTINUE READING