Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.

@article{Andrechek2000AmplificationOT,
  title={Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.},
  author={Eran R Andrechek and William R. Hardy and Peter M Siegel and Michael Rudnicki and Robert Cardiff and William J. Muller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 7},
  pages={3444-9}
}
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20-30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of mammary tumors, Neu expression in these models is driven by a strong viral promoter of questionable relevance to the human disease. To ascertain whether expression of… CONTINUE READING