Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening.

@article{Sugishita2013AmplificationOT,
  title={Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening.},
  author={Yoshiyuki Sugishita and Makoto Kammori and O. Yamada and Steven S. Poon and Makio Kobayashi and Naoyoshi Onoda and Kazuko Yamazaki and Tatsuya Fukumori and Kei-Ichi Yoshikawa and Hiroyuki Onose and Shinnya Ishii and Emiko Yamada and Tetsu Yamada},
  journal={International journal of oncology},
  year={2013},
  volume={42 5},
  pages={1589-96}
}
The human epidermal growth factor receptor 2 (HER2) proto-oncogene plays an important role in the development and progression of breast and gastric cancer. Monitoring of the HER2 status and treatment with trastuzumab was performed initially in breast cancer, and subsequently in gastric cancer. However, the HER2 status of thyroid cancer remains unexplored. Telomere alteration and telomerase activity have been observed in most human cancers and are known to be a feature of malignancy. The aims of… CONTINUE READING