Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival.

@article{Jrvel2006AmplificationOT,
  title={Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival.},
  author={Sally J{\"a}rvel{\"a} and Heikki Helin and Joonas A Haapasalo and Timo J{\"a}rvel{\"a} and Teemu T. Junttila and Klaus Elenius and Minna Tanner and Hannu Kalervo Haapasalo and Jorma Isola},
  journal={Neuropathology and applied neurobiology},
  year={2006},
  volume={32 4},
  pages={441-50}
}
Chromogenic in situ hybridization (CISH) was used to detect amplification of the epidermal growth factor receptor (EGFR) gene in tissue microarrays of tumours derived from 287 patients with grade II-IV diffuse astrocytomas. Amplification was found in 32% of the tumours with a highly significant association with histological grade (4% in grade II, 21% in grade III and 39% in grade IV; P < 0.001). Amplification of the EGFR gene was more common in primary than in secondary glioblastomas (41%vs. 16… CONTINUE READING

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