Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.

@article{McCann1995AmplificationOT,
  title={Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.},
  author={Amanda H McCann and Aiveen Kirley and Desmond N. Carney and N. Corbally and H. Melissa Magee and G. Keating and Peter A. Dervan},
  journal={British Journal of Cancer},
  year={1995},
  volume={71},
  pages={981 - 985}
}
The present study reports on the frequency of MDM2 gene amplification and MDM2 protein expression in a series of 100 breast carcinomas and its association with accumulation of the p53 protein. Of the 100 cases, frozen samples for 82 cases were available for Southern blotting. Three of the 82 (4%) demonstrated MDM2 gene amplification of up to 6-fold. Immunohistochemical analysis of the formalin-fixed, paraffin-embedded tumours demonstrated that 7/97 (7%) had nuclear expression for MDM2 in 10-50… CONTINUE READING

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MDM 2 gene amplification in metastatic osteocarcinoma

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