Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome.

@article{Rodrguez2004AmplificationOT,
  title={Amplification of the BRCA2 pathway gene EMSY in sporadic breast cancer is related to negative outcome.},
  author={Carmen Arbelo Rodr{\'i}guez and Luke Hughes-Davies and H{\'e}l{\`e}ne Vall{\'e}s and B{\'e}atrice Orsetti and Marguerite Cuny and Lisa Ursule and Tony Kouzarides and Charles Theillet},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 17},
  pages={5785-91}
}
DNA amplification at band q13 of chromosome 11 is common in breast cancer, and CCND1 and EMS1 remain the strongest candidate genes. However, amplification patterns are consistent with the existence of four cores of amplification, suggesting the involvement of additional genes. Here we present evidence strongly suggesting the involvement of the recently characterized EMSY gene in the formation of the telomeric amplicon. EMSY maps at 11q13.5, 100 kb centromeric to the GARP gene, which has been… CONTINUE READING
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