Amplification of superoxide anion generation in phagocytic cells by HIV-1 infection.

@article{Kimura1993AmplificationOS,
  title={Amplification of superoxide anion generation in phagocytic cells by HIV-1 infection.},
  author={Taizo Kimura and Masanori Kameoka and Kazuyoshi Ikuta},
  journal={FEBS letters},
  year={1993},
  volume={326 1-3},
  pages={232-6}
}
Amplification of superoxide (O2-) generation by HIV-1 infection was examined in two human myeloid-monocytic cell lines. The level of O2- generation in HL-60 after infection became significantly higher than that of the steady-state. A similar phenomenon was also shown in U937, but only after acquisition of O2- generation ability by differentiation to macrophages. By means of the NADPH oxidase-coupled responses in infected cells, we reconstituted the O2(-)-generating machinery in cell-free system… CONTINUE READING

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