Amplification of small molecule-inducible gene expression via tuning of intracellular receptor densities

@inproceedings{Wang2015AmplificationOS,
  title={Amplification of small molecule-inducible gene expression via tuning of intracellular receptor densities},
  author={Baojun Wang and Mauricio Barahona and Martin Buck},
  booktitle={Nucleic acids research},
  year={2015}
}
Ligand-responsive transcription factors in prokaryotes found simple small molecule-inducible gene expression systems. These have been extensively used for regulated protein production and associated biosynthesis of fine chemicals. However, the promoter and protein engineering approaches traditionally used often pose significant restrictions to predictably and rapidly tune the expression profiles of inducible expression systems. Here, we present a new unified and rational tuning method to… CONTINUE READING
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