Amplification of signal transduction capacity and down-regulation by drugs.

@article{Weber1999AmplificationOS,
  title={Amplification of signal transduction capacity and down-regulation by drugs.},
  author={George Weber and Fei Shen and H Yang and No{\'e}mi Prajda and Wenping Li},
  journal={Advances in enzyme regulation},
  year={1999},
  volume={39},
  pages={
          51-66
        }
}
Recent work in this Laboratory showed increased activity of PI 4-kinase, PIP kinase and PLC in various cancer cells, indicating a stepped-up capacity for signal transduction. This elevated potential was paralleled with increased concentration of the end product of signal transduction, IP3. Current investigations showed that in normal cells the activities of the specific phosphatases (which degrade PIP2 and PIP and oppose those of the synthetic enzymes) were 4 to 5 orders of magnitude higher… Expand
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