Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax.

@article{Suwanarusk2008AmplificationOP,
  title={Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax.},
  author={Rossarin Suwanarusk and Marina Chavchich and Bruce L. Russell and Anchalee Jaidee and Ferryanto Chalfein and Marion Barends and Budi Prasetyorini and Enny Kenangalem and Kim A. Piera and Usa Lek-Uthai and Nicholas M Anstey and Emiliana Tjitra and François Nosten and Qiuyan Cheng and Ric N Price},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 10},
  pages={
          1558-64
        }
}
BACKGROUND Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. METHODS In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax field isolates from Indonesia and Thailand. RESULTS Increased pvmdr1 copy number was present in 21% of isolates from Thailand (15/71) and none from Indonesia (0/114; P < .001). Compared with Indonesian isolates, the median IC(50) of Thai isolates was lower for chloroquine (36 vs. 114 nmol/L; P < .001) but higher for… CONTINUE READING
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