Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development

@article{Bello2007AmplificationON,
  title={Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development},
  author={Bruno C. Bello and Natalya Izergina and Emmanuel Caussinus and Heinrich Reichert},
  journal={Neural Development},
  year={2007},
  volume={3},
  pages={5 - 5}
}
In the mammalian brain, neural stem cells divide asymmetrically and often amplify the number of progeny they generate via symmetrically dividing intermediate progenitors. Here we investigate whether specific neural stem cell-like neuroblasts in the brain of Drosophila might also amplify neuronal proliferation by generating symmetrically dividing intermediate progenitors. Cell lineage-tracing and genetic marker analysis show that remarkably large neuroblast lineages exist in the dorsomedial… CONTINUE READING
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