Amplification of epidermal growth factor receptor gene in renal cell carcinoma.


Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

DOI: 10.1016/j.ejca.2010.01.011

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@article{ElHariry2010AmplificationOE, title={Amplification of epidermal growth factor receptor gene in renal cell carcinoma.}, author={Iman A. El-Hariry and Thomas B Powles and Mike R. Lau and Cora N. Sternberg and Alain Mure Ravaud and Hans von der Maase and Niko Zantl and Peter G. Harper and Fr{\'e}d{\'e}ric Rolland and Bruno Audhuy and Friederike Barthel and Jean-Pascal Machiels and Pina Patel and E. -D. Kreuser and Robert Edward Hawkins}, journal={European journal of cancer}, year={2010}, volume={46 5}, pages={859-62} }