Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification


Amyloid fibril formation has been implicated in the pathogenesis of neurodegenerative diseases. Fibrillation generates numerous conformers. Presumably, the conformers may possess specific biological properties, thus providing a biochemical framework for strains of prions. However, the precise relationship between various fibril conformers and their… (More)
DOI: 10.1038/emm.2017.1


2 Figures and Tables