Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.

@article{Jasper1990AmplificationOC,
  title={Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.},
  author={Jeffrey R. Jasper and Martin C Michel and Paul A. Insel},
  journal={Molecular pharmacology},
  year={1990},
  volume={37 1},
  pages={44-9}
}
Some beta-adrenergic receptor (beta AR) antagonists, in addition to blocking receptor-mediated responses, possess agonistic properties or intrinsic sympathomimetic activity (ISA). In this study we describe several techniques for amplification of cAMP levels as a measure of agonistic activity, and we apply these techniques to the study of beta AR antagonists with ISA. We show that 1) a variety of beta AR antagonists with ISA, including alprenolol and cyanopindolol, enhance cyclic AMP… CONTINUE READING

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