Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil.

Abstract

The present in vitro and in vivo studies examined the effects of modafinil on serotonergic transmission in the rat frontal cortex. In the in vitro study modafinil (0.3-30 microM) increased electrically-evoked, but not spontaneous, serotonin ([(3)H]5-HT) efflux from cortical slices in a concentration-dependent manner while the indirect serotonin agonist dl… (More)

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@article{Ferraro2000AmplificationOC, title={Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil.}, author={Luca Ferraro and Kjell Fuxe and Sergio Tanganelli and Mercedes Fernandez and Francis A. Rambert and Tiziana Antonelli}, journal={Neuropharmacology}, year={2000}, volume={39 11}, pages={1974-83} }