Amplification of SKI is a prognostic marker in early colorectal cancer.

  title={Amplification of SKI is a prognostic marker in early colorectal cancer.},
  author={Martin Buess and Luigi Maria Terracciano and J{\"u}rgen Reuter and Pierluigi Ballabeni and J Boulay and Urban Laffer and Urs F. Metzger and Richard Herrmann and Christoph Rochlitz},
  volume={6 3},
BACKGROUND Improved risk stratification of early colorectal cancer might help to better select patients for adjuvant treatment. Alterations in the transforming growth factor-beta (TGF-beta) pathway have frequently been found in colorectal cancer, but their impact on prognosis remains controversial. We therefore analyzed two transcriptional corepressors of the TGF-beta signaling pathway with respect to prognosis and prediction of chemotherapy benefit in early colorectal cancer. METHODS The… CONTINUE READING