Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary

Abstract

R-spondin1 is a secreted regulator of WNT signaling, involved in both embryonic development and homeostasis of adult organs. It can have a dual role, acting either as a mitogen or as a tumor suppressor. During ovarian development, Rspo1 is a key factor required for sex determination and differentiation of the follicular cell progenitors, but is… (More)
DOI: 10.1038/onc.2016.191

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Cite this paper

@inproceedings{Cian2017AmplificationOR, title={Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary}, author={M-C De Cian and Eva Pauper and Rosa Bandiera and Vincent Vidal and Sonia Sacco and Emilie Gr{\'e}goire and A A Chassot and Clara Panzolini and Donna Wilhelm and Eric A. Pailhoux and Sameh A. Youssef and Alain de Bruin and Katja J. Teerds and Andreas Schedl and Isabelle Gillot and M C Chaboissier}, booktitle={Oncogene}, year={2017} }