Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.

@article{Nanjundan2007AmplificationOM,
  title={Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.},
  author={Meera Nanjundan and Yasuhisa Nakayama and Kwai Wa Cheng and John P Lahad and Jinsong Liu and Karen Lu and Wen-Lin Kuo and Karen K. Smith-McCune and David Fishman and Joe W. Gray and Gordon B. Mills},
  journal={Cancer research},
  year={2007},
  volume={67 7},
  pages={
          3074-84
        }
}
Increased copy number involving chromosome 3q26 is a frequent and early event in cancers of the ovary, lung, head and neck, cervix, and BRCA1 positive and basal breast cancers. The p110alpha catalytic subunit of phosphoinositide-3-kinase (PI3KCA) and protein kinase Ciota (PKCiota) have previously been shown as functionally deregulated by 3q copy number increase. High-resolution array comparative genomic hybridization of 235 high-grade serous epithelial ovarian cancers using contiguous bacterial… CONTINUE READING
Highly Cited
This paper has 73 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

EVI and MDS/EVI are required for adult intestinal stem cell formation during postembryonic vertebrate development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2018

73 Citations

0510'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 73 citations based on the available data.

See our FAQ for additional information.