Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.

@article{Olsen2004AmplificationOH,
  title={Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.},
  author={Karen Ege Olsen and Helle Knudsen and Birgitte Bruun Rasmussen and Eva Balslev and Ann S{\o}egaard Knoop and Bent Ejlertsen and Kirsten Vang Nielsen and Andreas Sch{\"o}nau and Jens Overgaard},
  journal={Acta oncologica},
  year={2004},
  volume={43 1},
  pages={
          35-42
        }
}
New strategies for improving treatment of patients with breast carcinoma have focused on the HER2 oncoprotein with regard to response to traditional therapy regimes and the effect of a new drug specifically directed against the protein. Furthermore, the status of the topoisomerase IIalpha (TOP2A) gene has been suggested as a predictive marker of anthracycline treatment. In this study of 120 tumours, immunohistochemically detected HER2 overexpression with HercepTest has been compared to the HER2… CONTINUE READING

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