Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

@article{Robinson2003AmplificationOA,
  title={Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome},
  author={Hazel M. Robinson and Zo{\"e} J Broadfield and Kan Luk Cheung and Louise Harewood and Rachel L Harris and G Reza Jalali and Mary Martineau and Anthony V Moorman and Kerry E Taylor and S G Richards and Chris Mitchell and Christine J Harrison},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={2249-2250}
}
Recently, we confirmed that partial duplication of the long arm of chromosome 21, dup(21), including the 21q22 chromosomal region and amplification of AML1, is a recurring chromosomal abnormality in acute lymphoblastic leukemia (ALL). Multiple copies of the AML1 gene were identified in 20 patients during routine screening by interphase fluorescence in situ hybridization (FISH) for the presence of the TEL/AML1 fusion. Together with the sporadic cases reported in the literature, our study raised… CONTINUE READING