Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.

@article{Kunerth2004AmplificationAP,
  title={Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.},
  author={Svenja Kunerth and Matthias F Langhorst and Nadine Schwarzmann and Xianfeng Gu and Lijun Huang and Zhenjun Yang and Liangren Zhang and Steven J. Mills and Li-he Zhang and Barry V L Potter and Andreas H. Guse},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 10},
  pages={2141-9}
}
Ligation of the T-cell receptor/CD3 complex results in global Ca(2+) signals that are essential for T-cell activation. We have recently reported that these global Ca(2+) signals are preceded by localized pacemaker Ca(2+) signals. Here, we demonstrate for the first time for human T cells that an increase in signal frequency of subcellular pacemaker Ca(2+) signals at sites close to the plasma membrane, in the cytosol and in the nucleus depends on the type 3 ryanodine receptor (RyR) and its… CONTINUE READING
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