Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines.

@article{Imoto2000AmplificationAO,
  title={Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines.},
  author={Issei Imoto and Atiphan Pimkhaokham and Takashi Watanabe and Fumiko Saito-Ohara and Emiko Soeda and Johji Inazawa},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={276 1},
  pages={264-70}
}
Homeodomain transcription factors play important roles in directing cellular proliferation and differentiation. A TALE-superclass homeodomain protein, multifunctional repressor of TGFbeta-induced transcription. Here we report identification of TGIF2, a novel TALE-superclass homeodomain protein that shows distinct homology with TGIF, especially in its DNA-binding domain. TGIF2 is expressed ubiquitously in human tissues, with the highest levels being found in heart, kidney, and testis. The TGIF2… CONTINUE READING