Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer

@inproceedings{Cheng2011AmplificationAH,
  title={Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer},
  author={Qing Cheng and Jeffrey T. Chang and Joseph Geradts and Leonard M. Neckers and Timothy A. J. Haystead and Neil L. Spector and H Kim Lyerly},
  booktitle={Breast Cancer Research},
  year={2011}
}
Although human epidermal growth factor receptor 2 (HER2) positive or estrogen receptor (ER) positive breast cancers are treated with clinically validated anti-HER2 or anti-estrogen therapies, intrinsic and acquired resistance to these therapies appears in a substantial proportion of breast cancer patients and new therapies are needed. Identification of additional molecular factors, especially those characterized by aggressive behavior and poor prognosis, could prioritize interventional… CONTINUE READING
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Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients

  • P de Cremoux, F Valet, +13 authors F Spyratos
  • BMC Cancer
  • 2011
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