Amplification and expression of the c-myc oncogene in human lung cancer cell lines.

Abstract

Genetic changes involving the c-myc oncogene have been observed in human tumours. In particular, the c-myc gene is translocated in Burkitt's lymphoma and is amplified in the human promyelocytic leukaemia cell line, HL-60, which contains double minute chromosomes (DMs). More recently, an amplified c-myc gene has been positioned on a chromosomal homogeneous… (More)

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@article{Little1983AmplificationAE, title={Amplification and expression of the c-myc oncogene in human lung cancer cell lines.}, author={Charles D Little and Marion M. Nau and Desmond N. Carney and A. F. Gazdar and John D. Minna}, journal={Nature}, year={1983}, volume={306 5939}, pages={194-6} }