Amping up effort: effects of d-amphetamine on human effort-based decision-making.

  title={Amping up effort: effects of d-amphetamine on human effort-based decision-making.},
  author={Margaret C. Wardle and Michael Tilghman Treadway and Leah M Mayo and David H. Zald and Harriet de Wit},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={31 46},
Animal studies suggest the neurotransmitter dopamine (DA) plays an important role in decision-making. In rats, DA depletion decreases tolerance for effort and probability costs, while drugs enhancing DA increase tolerance for these costs. However, data regarding the effect of DA manipulations on effort and probability costs in humans remain scarce. The current study examined acute effects of d-amphetamine, an indirect DA agonist, on willingness of healthy human volunteers to exert effort for… CONTINUE READING
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The roles of dopamine and serotonin in decision making : evidence from pharmacological experiments in humans

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  • 2011
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