Amphotropic murine leukemia virus entry is determined by specific combinations of residues from receptor loops 2 and 4.

@article{Lundorf1999AmphotropicML,
  title={Amphotropic murine leukemia virus entry is determined by specific combinations of residues from receptor loops 2 and 4.},
  author={M D Lundorf and Finn Skou Pedersen and Bruce O'Hara and Lene G Pedersen},
  journal={Journal of virology},
  year={1999},
  volume={73 4},
  pages={3169-75}
}
Pit2 is the human receptor for amphotropic murine leukemia virus (A-MuLV); the related human protein Pit1 does not support A-MuLV entry. Interestingly, chimeric proteins in which either the N-terminal or the C-terminal part of Pit2 was replaced by the Pit1 sequence all retained A-MuLV receptor function. A possible interpretation of these observations is that Pit1 harbors sequences which can specify A-MuLV receptor function when presented in a protein context other than Pit1, e.g., in Pit1-Pit2… CONTINUE READING

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