Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells.

@article{Medoff1975AmphotericinBS,
  title={Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells.},
  author={Judith Medoff and Gerald Medoff and Martin Goldstein and David Schlessinger and G S Kobayaski},
  journal={Cancer research},
  year={1975},
  volume={35 9},
  pages={2548-52}
}
HeLa cells, which were selected for resistance to actinomycin D on the basis of decreaded penetration of the antibiotic into the cells, were treated with nontoxic concentrations of the polyene antibiotic amphotericin B. In the presence of amphotericin B, the cells became sensitive to the effects of actinomycin D, as demonstrated by loss of cell viability… CONTINUE READING