Amphotericin B-induced oxidative damage and killing of Candida albicans.

  title={Amphotericin B-induced oxidative damage and killing of Candida albicans.},
  author={Marcia L Sokol-Anderson and Janina Brajtburg and Gerald Medoff},
  journal={The Journal of infectious diseases},
  volume={154 1},
Amphotericin B (AmB) is known to bind to ergosterol in fungal cell membranes, but the precise mechanism of its toxicity to cells is as yet poorly understood. AmB autooxidizes, and it is possible that its antifungal effects could result from oxidative damage. Exposure of protoplasts of Candida albicans to AmB under hypoxic conditions reduced protoplast lysis by as much as 80% compared with incubations in air. Protoplasts were protected from AmB-induced lysis by exogenous catalase and/or… CONTINUE READING


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