Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.

  title={Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.},
  author={T. Yamamoto and Yuichi Umegawa and Hiroshi Tsuchikawa and S. Hanashima and N. Matsumori and Kosuke Funahashi and Sangjae Seo and W. Shinoda and Michio Murata},
  • T. Yamamoto, Yuichi Umegawa, +6 authors Michio Murata
  • Published 2019
  • Chemistry, Medicine
  • Biochemistry
  • Amphotericin B (AmB) is a polyene macrolide antibiotic clinically used as an antifungal drug. Its preferential complex-ation with ergosterol (Erg), the major sterol of fungal membranes, leads to the formation of barrel-stave-like ion chan-nel across a lipid bilayer. To gain a better understanding of the mechanism of action, a mode of lipid-bilayer spanning provides essential information. However, because of the lack of methodologies to observe it directly, it has not been revealed for the Erg… CONTINUE READING
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