Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics.

@article{Booth2010AmphiregulinMS,
  title={Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics.},
  author={Brian W. Booth and Corinne A Boulanger and Lisa H Anderson and Luc{\'i}a Jim{\'e}nez-Rojo and Cathrin Brisken and Gilbert H Smith},
  journal={Experimental cell research},
  year={2010},
  volume={316 3},
  pages={422-32}
}
Amphiregulin (AREG), a ligand for epidermal growth factor receptor, is required for mammary gland ductal morphogenesis and mediates estrogen actions in vivo, emerging as an essential growth factor during mammary gland growth and differentiation. The COMMA-D beta-geo (CDbetageo) mouse mammary cell line displays characteristics of normal mammary progenitor cells including the ability to regenerate a mammary gland when transplanted into the cleared fat pad of a juvenile mouse, nuclear label… CONTINUE READING