Amphiregulin is a mitogen for adult neural stem cells.

  title={Amphiregulin is a mitogen for adult neural stem cells.},
  author={Anna Helena Falk and Jonas Fris{\'e}n},
  journal={Journal of neuroscience research},
  volume={69 6},
Neurons are continuously generated from stem cells in the hippocampus and along the lateral ventricles in the adult brain. Neural stem cells can be propagated in vitro in the presence of epidermal growth factor (EGF) or fibroblast growth factor-2. We report here that amphiregulin, a growth factor related to EGF, is a mitogen for adult mouse neural stem cells in vitro and displays potency similar to that of EGF. Neural stem cell cultures can be initiated and the cells propagated as efficiently… CONTINUE READING
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