Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.

@article{Jacobs2009AmphiregulinAE,
  title={Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.},
  author={Bart Jacobs and Wendy De Roock and Hubert Piessevaux and Robin Van Oirbeek and Bart Biesmans and Jef De Schutter and Steffen Fieuws and Jo Vandesompele and Marc Peeters and Jean-Luc van Laethem and Yves Humblet and Fr{\'e}d{\'e}rique Penault-Llorca and Gert de Hertogh and Pierre Laurent-Puig and Eric Van Cutsem and Sabine Tejpar},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 30},
  pages={5068-74}
}
PURPOSE To study the power of the epidermal growth factor receptor (EGFR) epiregulin (EREG) and amphiregulin (AREG) ligands' expression in primary tumors to predict the outcome in patients with chemorefractory metastatic colorectal cancer (cmCRC) treated with the combination of cetuximab and irinotecan. PATIENTS AND METHODS Gene expression measurements and KRAS mutation analysis were performed on archival formalin-fixed paraffin-embedded primary tumors of 220 cmCRC patients. Response was… CONTINUE READING
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