Amphiregulin: Role in Mammary Gland Development and Breast Cancer

@article{McBryan2008AmphiregulinRI,
  title={Amphiregulin: Role in Mammary Gland Development and Breast Cancer},
  author={Jean McBryan and Jillian Howlin and Silvia Napoletano and Finian Martin},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2008},
  volume={13},
  pages={159-169}
}
Extensive epithelial cell proliferation underlies the ductal morphogenesis of puberty that generates the mammary tree that will eventually fill the fat pad. This estrogen-dependent process is believed to be essentially dependent on locally produced growth factors that act in a paracrine fashion. EGF-like growth factor ligands, acting through EGF receptors are some of the principal promoters of pubertal ductal morphogenesis. Amphiregulin is the most abundant EGF-like growth factor in the… 
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TLDR
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