Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics. Bin-Amphiphysin-Rvsp.

@article{Zhang2002AmphiphysinsRT,
  title={Amphiphysins: raising the BAR for synaptic vesicle recycling and membrane dynamics. Bin-Amphiphysin-Rvsp.},
  author={Bing Zhang and Andrew C Zelhof},
  journal={Traffic},
  year={2002},
  volume={3 7},
  pages={452-60}
}
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, have been postulated to play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). This review focuses on recent genetic studies of the role of amphiphysins in SV recycling and membrane morphogenesis. In the mouse, brain-specific amphiphysin I and II regulate, but are not essential for, SV recycling. The role of this regulation appears important, as mice deficient in these proteins have seizures and… CONTINUE READING
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