Amphiphysin I antisense oligonucleotides inhibit neurite outgrowth in cultured hippocampal neurons.

@article{Mundigl1998AmphiphysinIA,
  title={Amphiphysin I antisense oligonucleotides inhibit neurite outgrowth in cultured hippocampal neurons.},
  author={O Mundigl and Giancarlo Ochoa and Carol David and Vladimir I. Slepnev and Alexander Kabanov and Pietro De Camilli},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 1},
  pages={93-103}
}
Amphiphysin I is an SH3 domain-containing neuronal protein, enriched in axon terminals, which was reported to act as a physiological binding partner for dynamin I in synaptic vesicle endocytosis. Rvs167 and Rvs161, the yeast homologs of amphiphysin I, have been implicated in endocytosis, actin function, and cell polarity. Now we have explored the possibility that amphiphysin I also may have a role in actin dynamics and cell polarity by testing the effect of amphiphysin I suppression on neurite… CONTINUE READING

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