Amphiphilic oligoethyleneimine-β-cyclodextrin "click" clusters for enhanced DNA delivery.


Monodisperse amphiphilic oligoethyleneimine (OEI)-β-cyclodextrin (βCD) clusters have been prepared, and their potential as gene delivery systems has been evaluated in comparison with a nonamphiphilic congener. The general prototype incorporates tetraethyleneimine segments linked to the primary rim of βCD through either triazolyl or thioureidocysteaminyl… (More)
DOI: 10.1021/jo400993y