Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA.

@article{Yang2008AmphiphilicBC,
  title={Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA.},
  author={Zhihui Yang and Gaurav Sahay and Srikanth Sriadibhatla and Alexander V Kabanov},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 10},
  pages={1987-94}
}
This work for the first time demonstrates that synthetic polymers enhance uptake and nuclear import of plasmid DNA (pDNA) through the activation of cellular trafficking machinery. Nonionic block copolymers of poly(ethylene oxide) and poly(propylene oxide), Pluronics, are widely used as excipients in pharmaceutics. We previously demonstrated that Pluronics increase the phosphorylation of IkappaB and subsequent NFkappaB nuclear localization as well as upregulate numerous NFkappaB-related genes… CONTINUE READING

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