Amphiphilic Macromolecules on Cell Membranes: From Protective Layers to Controlled Permeabilization

@article{Marie2014AmphiphilicMO,
  title={Amphiphilic Macromolecules on Cell Membranes: From Protective Layers to Controlled Permeabilization},
  author={Emmanuelle Marie and Sandrine Sagan and Sophie Cribier and C Tribet},
  journal={The Journal of Membrane Biology},
  year={2014},
  volume={247},
  pages={861-881}
}
Antimicrobial and cell-penetrating peptides have inspired developments of abiotic membrane-active polymers that can coat, penetrate, or break lipid bilayers in model systems. Application to cell cultures is more recent, but remarkable bioactivities are already reported. Synthetic polymer chains were tailored to achieve (i) high biocide efficiencies, and selectivity for bacteria (Gram-positive/Gram-negative or bacterial/mammalian membranes), (ii) stable and mild encapsulation of viable isolated… CONTINUE READING