Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

@article{Klibanov1990AmphipathicPE,
  title={Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes},
  author={Alexander L. Klibanov and Kazuo Maruyama and Vladimir Torchilin and Leaf Huang},
  journal={FEBS Letters},
  year={1990},
  volume={268}
}

Stealth Liposomes: Five Years On

P EG-lipid derivatives such as PEG-distearoylphosphatidylethanolamine (PEG-DSPE) are particularily useful because of their ease of preparation and relative lack of expense.

STABILIZATION AND REGULATED FUSION OF LIPOSOMES CONTAINING A CATIONIC LIPID USING AMPHIPATHIC POLYETHYLENEGLYCOL DERIVATIVES

It is shown here that large unilamellar vesicles (LUVs) containing Dope and the cationic lipid, N,N-dioleoyl-N, N-dimethylammonium chloride (DODAC) can be stabilized against serum-induced aggregation and fusion by inclusion of at least 2 mol% of PEG coupled to phosphatidylethanolamine or ceramide.

Sterically stabilized liposomes.

POLY(HPMA)-COATED LIPOSOMES DEMONSTRATE PROLONGED CIRCULATION IN MICE

Semitelechelic poly(HPMA) with single- or double-oleic acid hydrophobic terminus were synthesized and incorporated into the surface of liposome composed of phosphatidylcholine and cholesterol, which provided strong steric protection for liposomes, increasing their circulation time and decreasing liver accumulation in experimental mice.

Doxorubicin encapsulated in long-circulating thermosensitive liposomes

Inclusion of PEG or GM1 endowed TSL with prolonged circulation ability, resulting in increased blood levels of liposomes and decreased reticuloendothelial system (RES) uptake over 6 hours after injection.
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