Amphipathic homopolymers for siRNA delivery: probing impact of bifunctional polymer composition on transfection.

  title={Amphipathic homopolymers for siRNA delivery: probing impact of bifunctional polymer composition on transfection.},
  author={Christian Buerkli and Soo Hyeon Lee and Elena V. Moroz and Mihaiela C. Stuparu and Jean‐Christophe Leroux and Anzar Khan},
  volume={15 5},
In this study, we systematically explore the influence of the lipophilic group on the siRNA transfection properties of the polycationic-based delivery vectors. For this, a novel and modular synthetic strategy was developed for the preparation of polymers carrying a cationic site and a lipophilic group at each polymer repeat unit. These bifunctional polymers could form a complex with siRNA and deliver it to human colon carcinoma cells (HT-29-luc). In general, transfection capability increased… 

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