Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.

@article{Elazar2003AmphipathicHL,
  title={Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication.},
  author={Menashe Elazar and Kwang Ho Cheong and Ping Liu and Harry B Greenberg and Charles M. Rice and Jeffrey S. Glenn},
  journal={Journal of virology},
  year={2003},
  volume={77 10},
  pages={6055-61}
}
We identified an N-terminal amphipathic helix (AH) in one of hepatitis C virus (HCV)'s nonstructural proteins, NS5A. This AH is necessary and sufficient for membrane localization and is conserved across isolates. Genetically disrupting the AH impairs HCV replication. Moreover, an AH peptide-mimic inhibits the membrane association of NS5A in a dose-dependent manner. These results have exciting implications for the HCV life cycle and novel antiviral strategies. 

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